I've got a great big gaping hole right through the center of me, and I can never drink enough, nor take enough drugs to ever fill it.
If you find yourself smoking ice and drinking vodka with friends at 11am on a Sunday morning you deserve the hellish feeling that ensues whilst sitting at work at 11am on Monday morning.
It is pure physics: "for every action there is an equal and opposite reaction."
Actually, it is pure chemistry - but then I wouldn't be able to fit a nice quote in.
At least I still have a sense of humor.